Effect of grape seed extract on improving memory and learning impairment induced by streptozotocin in male rat

ABSTRACT

Background and Objective: Alzheimer's disease is an age-related disease that is characterized by dementia and loss of neurons in the brain. It has been shown that brain oxidative stress plays an important role in aging and neurodegenerative disorders. This study was done to evaluate the effect of grape seed extract [GSE] on memory impairment induced by intracerebroventricular [ICV] injection of streptozotocin [STZ] in animal model of Alzheimer's disease