[Investigation of Sesame oil and calcium hydroxide effectiveness on nonsurgical debridement of third degree burns in male rats]

ABSTRACT

The presence of necrotic tissue is an important problem in patients with deep burns. In this study the effectiveness of Sesame oil plus calcium hydroxide on debridment of third degree burns is investigated in rats. This experimental study is performed on 40 Wistar rats. After anesthesia, both flanks of rats were shaved, then third degree burns with 3cm diameters were produced using boiling water. Rats were divided into 4 groups randomly. One side of the first three groups was treated by fibrinolysin pomade and the other side in group one to third was treated using 1, 2.5 and 5% Kenhide pomade. In the forth group wounds were healed without treatment and spontaneously. In each group and wound, the time of necrotic tissue detachment and then formation of granulation tissue was documented in a checklist. Data was analyzed using paried T and ANOVA tests. Results showed that comparing the three different concentrations of Kenhide the lowest debridment time with 16.6 days was related to 5% Kenhide [p=0.001]. On the other hand there was relatively no significant difference between debridment time in case group and the first control grpoup [p=0.053], but this difference was significant in case and the second control groups [p< 0.001]. There was also a significant difference between the time of granulation tissue formation in using 5% Kenhide and first control groups [p< 0.01]. Using Kenhide 5% pomade not only causes no injury to healthy tissues but also can be compared to fibrinolysin pomade in necrotic tissue debridment. More investigation is recommended in this field