Activation of toll-like receptors 2 by high-mobility group box 1 in monocytes from patients with ischemic stroke

ABSTRACT

Background: Stroke is a leading cause of death all around the world, and ischemic stroke is considered to be the most common stroke type. Toll-like receptors [TLRs] are important molecules for detection of both pathogen invasion and tissue damage. In this regard, the purpose of this study was to assess the expression level of TLR2 on monocytes in patients with ischemic stroke and to evaluate the expression change profile following high-mobility group box 1 [HMGB1] stimulation