Suppressive effect of constructed shrnas against apollon induces apoptosis and growth inhibition in the hela cell line

ABSTRACT

Background: Cervical cancer is the second most common female cancer worldwide. Inhibitors of apoptosis proteins [IAPs] block apoptosis; therefore, therapeutic strategies targeting IAPs have attracted the interest of researchers in recent years. Apollon, a member of IAPs, inhibits apoptosis and cell death. RNA interference is a pathway in which small interfering RNA [siRNA] or shRNA [short hairpin RNA] inactivates the expression of target genes. The purpose of this study was to determine the effect of constructed shRNAs on apoptosis and growth inhibition through the suppression of apollon mRNA in HeLa cell line