Frequency of null allele of Human Leukocyte Antigen-G [HLA-G] locus in subjects to recurrent miscarriage

ABSTRACT

Background: Human leukocyte antigen-G [HLA-G] is a non-classical class I molecule highly expressed by extravillous cytotrophoblast cells. Due to a single base pair deletion, its function can be compensated by other isoforms. Investigating the frequency of null allele in Recurrent Miscarriage [RM] subjects could be useful in understanding the relationship between frequency of this allele and RM in a given population