[The study of peripheral blood mononuclear cells activity of women with polycystic ovary syndrome [PCOS] by co-culture with breast cancer cell lines compared with the healthy controls]

ABSTRACT

Introduction: polycystic ovary Syndrome [PCOS] is one of the most prevalent endocrinology disorders in women, in whom the state of systemic inflammatory cytokines, especially TNF-alpha is the main reason for immunological disturbances. Some PCOS manifestations such as infertility, hyperandrogenism, obesity and chronic inflammation are considered as risk factors for breast cancer. The risk of developing breast cancer in women with PCOS is being investigated in some epidemiological studies. In this research, the ability of peripheral blood mononuclear cells [PBMCs] of women with PCOS to develop antitumor response was studied and evaluated using an experimental co-culture approach between PBMCs and breast tumor cell lines