Synthesis, spectral analysis and biological evaluation of Nalkyl/ aralkyl/aryl-4-chlorobenzenesulfonamide derivatives
Pakistan Journal of Pharmaceutical Sciences. 2016; 29 (5): 1489-1496
em Inglês
| IMEMR
| ID: emr-183625
ABSTRACT
New potent organic compounds were synthesized with an aim of good biological activities such as antibacterial and anti-enzymatic. Three series of sulfonamide derivatives were synthesized by treating N-alkyl/aryl substituted amines [2a-f] with 4-chlorobenzensulfonyl chloride [1] to yield N-alkyl/aryl-4-chlorobenzenesulfonamide[3af] that was then derivatized by gearing up with ethyl iodide [4], benzyl chloride [5] and 4-chlorobenzyl chloride [6] using sodium hydride as base to initialize the reaction in a polar aprotic solvent [DMF] to synthesize the derivatives, 7a-f, 8afand 9a-f respectively. Structure elucidation was brought about by IR, 1H-NMR and EIMS spectra for all the synthesized molecules which were evaluated for their antibacterial activities and inhibitory potentials for certain enzymes
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Índice:
IMEMR (Mediterrâneo Oriental)
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2016
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