Chlorpyrifos toxicity in mouse cultured cerebellar granule neurons at different stages of development: additive effect on glutamate-induced excitotoxicity

ABSTRACT

Objective: Chlorpyrifos [CPF] is a neurotoxic organophosphorus [OP] insecticide. Its mechanism of action includes oxidative stress, excitotoxicity, and inhibition of the acetylcholinesterase enzyme [AChE]. The aim of the present study is to investigate CPF toxicity in mature and immature cerebellar granule neurons [CGNs], as well as its effect on glutamate induced excitotoxicity