Synthesis and screening of some new N-alkyl/aralkyl-N-[3,4-methylenedioxybenzyl]-4-substituted benzenesulfonamides as potential antibacterial agents
Pakistan Journal of Pharmaceutical Sciences. 2016; 29 (6): 2109-2117
em Inglês
| IMEMR
| ID: emr-184158
ABSTRACT
The various p-substituted benzenesulfonyl chlorides [2a-e] were treated with [3,4-methylenedioxy] benzylamine [1] in the presence of aqueous Na2CO3 solution to synthesize N-[3,4-methylenedioxybenzyl]-4-substitutedbenzenesulfonamides [3a-e]. The synthesized molecules were further converted into corresponding Nethyl/benzyl/4-flourobenzyl-N-[3,4-methylenedioxybenzyl]-4-substitutedbenzenesulfonamides [7a-e, 8a-e, 9a-e] on reaction with ethyl iodide [4], benzyl chloride [5] and 4-flourobenzyl chloride [6] in the presence of sodium hydride using N,N-dimethylformamide as solvent. The structure elucidation was processed through different spectral techniques including IR, [1]H-NMR and EIMS. The screening of the synthesized molecules against Gram-bacterial strains, to evaluate antibacterial activity, showed them moderately good inhibitors as shown by their low MIC values
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Índice:
IMEMR (Mediterrâneo Oriental)
Tipo de estudo:
Estudo de rastreamento
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2016
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