Chronic fluoxetine treatment upregulates the activity of the ERK1/2-NF-kB signaling pathway in the hippocampus and prefrontal cortex of rats exposed to forced-swimming stress

ABSTRACT

Objectives: The aim of this study was to explore whether or not the antidepressant actions of fluoxetine [FLX] are correlated with extracellular signal-regulated kinase 1 and 2 [ERK1/2] and nuclear factor k-light chain enhancer of activated B cells [NF-kB] in the hippocampus [HC] and prefrontal cortex [PFC] of rats