Molecular and immunohistochemical study of platelet derived growth factor receptor alpha in kit negative gastrointestinal stromal tumors; the first report from Iran

ABSTRACT

Background: Gastrointestinal stromal tumors [GISTs] are potentially malignant tumors; however their behavior and response to treatment is dependent on the type of mutation and immunohistochemical expression of antigens. It is recommended to perform routine molecular and immunohistochemical tests in KIT and platelet derived growth factor receptor alpha [PDGFRA] molecules for making decision regarding targeted therapy and prediction of the behavior of the tumor