Methylation status of H19/IGF2 differentially methylated region in in vitro human blastocysts donated by healthy couples
IBJ-Iranian Biomedical Journal. 2017; 21 (1): 16-23
em Inglês
| IMEMR
| ID: emr-185663
ABSTRACT
Backgrund Imprinted genes are a unique subset of few genes, which have been differentially methylated region [DMR] in a parental origin-dependent manner during gametogenesis, and these genes are highly protected during pre-implantation epigenetic reprogramming. Several studies have shown that the particular vulnerability of imprinting genes during suboptimal pre- and peri-conception micro-environments often is occurred by assisted reproduction techniques [ART]. This study investigated the methylation status of H19/IGF2 DMR at high-quality expanding/expanded human blastocysts donated by healthy individuals to evaluate the risks linked to ART
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Blastocisto
/
Técnicas In Vitro
/
Impressão Genômica
/
Ilhas de CpG
/
Técnicas de Reprodução Assistida
/
Epigênese Genética
/
Irã (Geográfico)
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Iran. Biomed. J.
Ano de publicação:
2017
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