Effect of chongmyungtang, a traditional Korean polyherbal formula, on the Pharmacokinetic profiles of donepezil in rats
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (1): 97-103
em Inglês
| IMEMR
| ID: emr-185746
ABSTRACT
Chongmyungtang [CMT] is a famous Korean herbal medicine for improving learning and memory, which has been reported to have anti-cholinergic and neuroprotective effects. Therefore, drug-drug interactions were examined between CMT and donepezil as a first screening of combination therapy for cognitive deficits. Rats received oral coadministration of donepezil with distilled water as a control or donepezil with CMT as a combination. The distilled water or CMT was co-administered at intervals within 5min after donepezil or 1.5h intervals. The plasma samples were analyzed for donepezil concentration and its pharmacokinetic parameters of T[max], C[max], AUC, t[1/2] and MRT[inf]. In the single co-administration at intervals within 5min, donepezil was detected lower in the combination than control at 0.5h and 2h post-treatment [P<0.05]. In addition, the combination showed significant increases in MRT[inf] compared to the control [P<0.05]. This suggests drug-drug interactions between donepezil and CMT in the co-administration within 5 min. However, no meaningful differences were found in the pharmacokinetic profiles of donepezil by single dosing with CMT at 1.5h intervals and even by the repeated dosing for a week at 1.5h intervals potential combination therapy of donepezil with CMT
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Plantas Medicinais
/
Transtornos Cognitivos
/
Interações Ervas-Drogas
/
Fitoterapia
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2017
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