Prophylactic and therapeutic effect of Punica granatum in trinitrobenzene sulfonic acid induced inflammation in rats
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (1): 155-162
em Inglês
| IMEMR
| ID: emr-185753
ABSTRACT
Pomegranate [Punica granatum L., Punicaceae] contains varieties of antioxidants and phytochemicals; there are evidences that phytochemicals and antioxidants play a vital role in reducing inflammation. Hence this investigation was planned to assess the outcome of Punica granatum on trinitrobenzene sulfonic acid provoked colitis in rats at 2, 5 and 8ml/kg of the body weight. The effect of P. granatum was assessed in two group i.e. prophylaxis as pre-colitis and therapeutic as post-colitis. After completion of dosing in both the groups, macroscopic and histological examination of colon was carried out along with estimation of serum myeloperoxidase, glutathione, alkaline phosphate, fibrinogen and C-reactive protein. In prophylactic procedure P. granatum revealed significant [P=0.05] changes in biochemical markers of inflammation at 5 and 8ml/kg doses. However in therapeutic procedure significant change was observed only at 8ml/kg. Thus results of the present study suggest that P. granatum have a role in prevention as well as treatment of inflammation
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Plantas Medicinais
/
Ratos Wistar
/
Modelos Animais de Doenças
/
Relação Dose-Resposta a Droga
/
Fitoterapia
/
Anti-Inflamatórios
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2017
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