Melissa officinalis acidic fraction protects cultured cerebellar granule neurons against beta amyloid-induced apoptosis and oxidative stress
Cell Journal [Yakhteh]. 2017; 18 (4): 556-564
em Inglês
| IMEMR
| ID: emr-185781
ABSTRACT
Objective:
Extracellular deposition of the beta-amyloid [A beta] peptide, which is the main finding in the pathophysiology of Alzheimer's disease [AD], leads to oxidative damage and apoptosis in neurons. Melissa officinalis [M. officinalis] is a medicinal plant from the Lamiaceae family that has neuroprotective activity. In the present study we have investigated the protective effect of the acidic fraction of M. officinalis on A beta-induced oxidative stress and apoptosis in cultured cerebellar granule neurons [CGN]. Additionally, we investigated a possible role of the nicotinic receptor
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Cerebelo
/
Apoptose
/
Estresse Oxidativo
/
Grânulos Citoplasmáticos
/
Doença de Alzheimer
/
Camundongos
Limite:
Animais
Idioma:
Inglês
Revista:
Cell J. [Yakhteh]
Ano de publicação:
2017
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