MTHFR Gene polymorphisms and susceptibility to Migraine Attacks
Archives of Medical Laboratory Sciences. 2015; 1 (2): 61-66
em Inglês
| IMEMR
| ID: emr-186327
ABSTRACT
Background:
Migraine consisting of migraine with aura [MA] and migraine without aura [MO] is a painful neurovascular disorder affecting approximately 16% of the general population. A combination of genetic and environmental factors is involved in the pathogenesis of migraine. The MTHFR enzyme is involved in homocysteine [Hcy] metabolism and it has been reported that 1298 A to C and 677 C to T mutations in the MTHFR gene are associated with an increased in plasma Hcy levels. Hcy is a highly reactive amino acid and causes endothelial injury. Because a plausible theory about vascular impairment in migraine, it is considered that mutations in MTHFR gene and folate metabolism are associated with migraine
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Índice:
IMEMR (Mediterrâneo Oriental)
Idioma:
Inglês
Revista:
Arch. Med. Lab. Sci.
Ano de publicação:
2015
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