Determination of hepatitis B virus genotypes in Yazd, Central Province of Iran

Background and Aims: hepatitis B virus [HBV] infects the liver and causes acute and chronic hepatitis, hepatocellular carcinoma and cirrhosis. HBV has been divided to eight genotypes [A-H] and subgenotypes of A, B, C and F. For the first time, we determined HBV genotypes in infected samples by INNO-LiPA method in Yazd, central province of Iran

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Materials and Methods: this study was performed on samples suspected of HBV infection. The sera of fifteen out of ninety-five samples that had shown positive results by RT-PCR were used for HBV genotyping by using INNO-LiPA HBV genotyping assay

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Results and Conclusions: seven [46.7%] out of fifteen samples were female. The mean age of the patients was 37.8+/-14.3 years. The average number copy of HBV in infected samples was 1.04×10[6]+/-4.74×10[5] Copies/ml. All fifteen infected samples had genotype D. Our results showed that HBV genotype D was the only detectable genotype in Yazd, central province of Iran. A further study with a larger sample size in different provinces of Iran is needed to identify HBV genotypes in Iran