Evaluation of anti-inflammatory and anti-oxidant potential of seed extracts of Vernonia anthelmintica
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (3): 755-760
em Inglês
| IMEMR
| ID: emr-186469
ABSTRACT
Seeds of Vernonia anthelmintica in the form of Ethanol seed extract of Vernonia anthelmintica [EEVA], Hexane extract of Vernonia anthelmintica [HEVA] and water decoction of Vernonia anthelmintica [WDVA] were evaluated for their in-vivo anti-Inflammatory potential in carrageenan induced rat paw model. The results were compared to anti-inflammatory activity of standard drug [ibuprofen] and untreated groups. In-vitro evaluation of antioxidant potential of EEVA and HEVA were also conducted by "DPPH scavenging assay". The results of present study depicts that HEVA and EEVA in higher dose possess a strong anti-inflammatory potential as compared to standard antiinflammatory drugs, whereas WDVA showed milder anti-inflammatory potential. DPPH assay has revealed strong antioxidant potential of EEVC with the percentage Radical Scavenging activity [%RSA] of 89.709 at concentrations of 500 ul as compared to standard drugs gallic acid [23.436+/-0.43] and acetyl salicylic acid [111.44+/-0.7] at concentrations of 95.95 micro M. The other extract HEVC has shown to have insignificant %RSA at the concentration of 500micro l. Hence the present study revealed that selected extracts of Vernonia anthelmintica exhibited significant in-vitro antioxidant and invivo anti-inflammatory potential
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Índice:
IMEMR (Mediterrâneo Oriental)
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2017
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