hepato protective effect of pioglitazone ischemic reperfusion injury

ABSTRACT

Hepatic ischemia/reperfusion [I/R] injury is the main cause of hepatic damage and is inevitable after hepatic surgery, liver transplantation, shock, trauma. Despite the recent improvements in liver preservation and surgical techniques, hepatic I/R injury remains an important clinical complication. To control this complicated physiological as well as pathological process, further studies are required to find out the key pathway and a novel therapeutic approach. PPAR gamma may be a protective regulator against ischemic damage. The aim of this study is to study the effect of pioglitazone on hepatic ischemic-reperfusion injury and compare its effect with ischemic preconditioning