Role of T and B lymphocytes in spontaneous lymphocyte proliferation in chronic inflammatory periodontal disease

ABSTRACT

Spontaneous lymphocyte responses of whole mononuclear cells [MNCs, T-lymphocytes and B-lymphocyte in patients with periodontal disease and theircontrols were studied in this work utilizing the tritiated thymidine uptakeassay. The periodontitis patients exhibited lower lymphoproliferativeresponse of MNCs compared with the controls. However, theB-lymphoproliferative response of patients showed the highest proliferativeresponse compared with that of all cell types studied. This finding maysuggest that the elimination of T-cell affects the hyperresponsiveness ofB-lymphocyte state