Alpha alumina nanoparticle conjugation to cysteine peptidase A and B: an efficient method for autophagy induction
AJMB-Avicenna Journal of Medical Biotechnology. 2017; 9 (2): 71-81
em Inglês
| IMEMR
| ID: emr-187786
ABSTRACT
Background:
autophagy as a cellular pathway facilitates several immune responses against infection. It also eliminates invading pathogens through transferring content between the cytosol and the lysosomal vesicles and contributes to the cross-presentation of exogenous antigens to T lymphocytes via MHC class I pathway. Autophagy induction is one of the main targets for new drugs and future vaccine formulations. Nanoparticles are one of the candidates for autophagy induction. Cysteine Peptidase A [CPA] and Cysteine Peptidase B [CPB] are two members of papain family [Clan CA, family C1] enzyme that have been considered as a virulence factor of Leishmania [L.] major, making them suitable vaccine candidates. In this research, Leishmania major cysteine peptidase A and B [CPA and CPB] conjugation to alpha alumina nanoparticle was the main focus and their entrance efficacy to macrophages was assessed
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Índice:
IMEMR (Mediterrâneo Oriental)
Idioma:
Inglês
Revista:
Avicenna J. Med. Biotechnol.
Ano de publicação:
2017
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