Antibody response against actinobacillus actinomycetemcomitans endotoxin in experimental periodontitis

ABSTRACT

Experimental periodontitis was induced in 18 Sprague-Dawley rats divided intothree groups. They were infected by fresh isolates of actinobacillus actinomycetemcomitans [Aa] strain [Y4]. A positive control group was neitherorally infected nor injected by Aa. Antibodies against Aa endotoxin weremeasured in all groups by ELISA immunoassay. Antibodies against Aa endotoxinwere detected in the increased as the time of exposure to Aa was increased. Antibody concentration in orally infected rats did not reach the antibodyconcentration detected in the injected group. There was a mild antibodyresponse against Aa endotoxins, which can be considered as a protectivemechanism aiming to neutralizing the deleterious effect of Aa endotoxins onthe host