P53 protein expression in dental follicle, dentigerous cyst, odontogenic keratocyst, and inflammatory subtypes of cysts: an immunohistochemical study

ABSTRACT

Objectives: An odontogenic keratocyst [OKC] is a developmental odontogenic cyst with aggressive clinical behavior. This cyst shows a different growth mechanism from the more common dentigerous cyst and now has been renamed as a keratocystic odontogenic tumor [KCOT]. Inflammation can assist tumor growth via different mechanisms including dysregulation of the p53 gene. This study aims to assess and compare the expression of tumor suppressor gene p53 in inflamed and non-inflamed types of OKC and dentigerous cyst