Second-derivative spectrophotometric determination of some weakly absorbing drugs in their formulations

ABSTRACT

A rapid and sensitive second-derivative spectrophotometric method was described for the estimation of some weakly absorbing drugs in their pharmaceutical dosage forms. The interference of the formulation excipients in conventional UV spectrophotometric methods is eliminated by the application of the proposed methods. Good linearity of D2 values versus concentration for different drugs permits their assay in tablets/vials with high accuracy and precision. The results of the proposed method are comparable with those of the official method and are more accurate than the conventional spectrophotometric method: