Research on the influence of bilateral oophorectomy on the BMD, body components and sex hormone of women during the perimenopause

ABSTRACT

To investigate the effect of bilateral oophorectomy on bone mineral density, body composition and sex hormone of peri-menopause women. 33 cases of peri-menopause women patients performed bilateral oophorectomy were chosen from xxx gynaecology and obstetrics department of xxx hospital from January 1[st],2014 to Dec31[st], 2014. And the 33 cases were taken as ovariectomy group. 35 women who were the naturally postmenopausal after menopause collected in clinic and in the same period with the patients of ovariectomy group were taken in control group. American GE-Lunar-Prodigy dual energy X-ray absorptiometry and chemiluminescence method were employed to detect the bone mineral density, fat content, muscle content and sex hormone of the patients in both groups at the 6[th] and 12[th] month after menostasis. There was no statistical significance on the comparative difference of bone mineral density, fat content and muscle content at the 6[th] and 12[th] month after menostasis between both groups, P>0.05. At the 6[th] month after menostasis, the estradiol [E[2]] level in ovariectomy group was significantly lower than that of control group [[14.79+/- 22.17]U/L vs [32.74+/- 31.02U/L]], P<0.05; at the 12[th] month after menostasis, it had the statistical significance for the comparative difference between the level of E[2] and and follicle-stimulating hormone [FSH] in ovariectomy group and that in control group, E[2] [8.09+/- 4.38]U/L vs [25.92+/- 3.53]U/L; FSH [64.88+/- 18.39]U/L vs [40.69+/- 31.63]U/L], P<0.05. The change of E[2] and FSH were the main symptom of peri-menopausal women within 12 months after bilateral oophorectomy, the decrease of E[2] level had no effect on bone mineral density, fat content and muscle content