Synthesis and evaluation for Antimicrobial and antihistaminic properties of new thiosemicarbazide and triazole derivatives of triazolo [4,3-a] quinazolin-5 [H] -ones

ABSTRACT

Several triazolo [4,3-a] quinazolinones, bearing in the 1-position diverse thiosemicarbazide [compounds Xa-I] and triazole moieties [compounds XIa-I], were synthesized. The products were found to be devoid of antimicrobial properties and the preliminary antihistaminic screening of two products revealed insignificant activity