Development of prolonged release ketoprofen tablets

ABSTRACT

Prolonged release ketoprofen tablet formulations were prepared by the fusion method using different concentrations of hydrogenated castor oil or a mixture of hydrogenated castor oil and polyethylene glycol 6000. The release of the prepared formulations, in comparison with a st and ard ketoprofen sustained release capsule, was performed on USP XXII dissolution apparatus type 2. The dissolution medium was 0.1N HCl and rotated at 100 rpm. The pH of the dissolution medium was changed after one hour to a pH 7.4. The release study revealed that only 4 mg of hydrogenated castor oil produced tablets with a release pattern similar to that of the st and ard capsule. The drug release mechanism from all formulations was calculated and found in most cases to be of Fickian's diffusion type