Volumetric determination of piroxicam in presence of degradation product

ABSTRACT

An indirect volumetric method for the determination of piroxicam is developed. It depends on the reaction of piroxicam with a measured excess of ammonium-cerric-sulfate in sulfuric acid medium. The excess cerric is back titrated with st and ard ammonium ferrous sulfate using ferroin as indicator. The molar ratio of the reactants was determined to be one drug to four ammonium-cerric-sulfate. The method was successfully applied for the determination of piroxicam in pharmaceutical preparations. The presence of 2-aminopyridine, the degradation drug product, did not interfere with the accurate determination of piroxicam. The validity of the method was checked using the st and ard addition technique