Adipose derived stem cells affect miR-145 and p53 expressions of co-cultured hematopoietic stem cells

ABSTRACT

Objective: umbilical cord blood is used for transplantation purposes in regenerative medicine of hematological disorders. MicroRNAs are important regulators of gene expression that control both physiological and pathological processes such as cancer development and incidence. There is a new relation between p53 [tumor suppressor gene] and miR-145 [suppressor of cell growth] upregulation. In this study, we have assessed how adipose-derived stem cells [ADSCs] affect the expansion of hematopoietic stem cells [HSCs], as well as miR-145 and p53 expressions