Study of relationship between g894t variant of endothelial Nitric oxide synthase gene and acute ischemic stroke

ABSTRACT

Background: cerebral stroke [CS] is considered as one of the major causes of death and disability worldwide. Ischemic stroke is the most common type of stroke in Egypt, as in other countries, accounting for 43% to 79% of all stroke types .There are some traditional factors that increase the risk of ischemic stroke such as hypertension and smoking, but genetic risk factors, suggested by evidence from inheritance-based studies, might contribute to predisposition to ischemic stroke. Among investigated genetic variations of eNOS is G894T polymorphism that leads to a change of glutamate to aspartate at site 298 and is said to have increased susceptibility to cleavage of eNOS enzyme which contribute to the development of stroke