Phytoformulation of Sassurea lappa plant extract: a single blind, noninvasive and split face study of cream on various skin parameters

ABSTRACT

Saussurea lappa [SL] has been reported for its antioxidant and anti-ageing properties. Due to this reason it can be incorporated in a stable phytoformulations for cosmetic use. The objective of the study was to evaluate the anti-aging potential of cosmetic o/w emulsion containing the botanical extract of SL. An emulsion [o/w] was prepared using TEGO[registered] Care 450 [Polyglceryl-3-Methyl Glucose Distearate] emulsifier and final emulsion was loaded with 4 % extract of SL in aqueous phase. This emulsion evaluated for its antioxidant and anti-ageing properties on healthy human subjects using a non-invasive technique called surface evaluation of living skin [SELS]. The formulation containing SL extract showed significant [pSkin roughness [SEr] as -3.13%, -6.26%, -9.39%; Skin Scaliness [SEsc] as - 4.19%, -8.39%, -12.58%; Skin wrinkles [SEw] as -0.5%, -1.08%, -1.63%; and Skin smoothness [SEsm] as 3.28%, 6.57%, 9.85%, respectively, after 30, 60 and 90 days of continous use. Topical application of the cosmetic cream containing SL extract exerts have a significant anti-aging effects, perhaps due to the presence of Kaempferol, gallic acid, Caffeic acid and other essential phenolics