Calcium regulation in alzheimer's disease: mechanistic understanding

ABSTRACT

This study is systematic review of the research, focused on all possible pathways involved in calcium [Ca2+] regulation in order to utilize them in the control and remediation of Alzheimer's disease [AD], because Ca2+ plays important role in pathogenesis of AD. Electronic databases, Science Direct and PubMed/Medline, for relevant publications between 2000- April 2017, were searched. Ca2+ ions are very important in cell signaling in body, specially the neuronal signaling. Many pathways are involved in normal neuronal Ca2+ signaling. AD is one of the most commonly known neurodegenerative disorders, causing dementia and some other neuropathological signs in mostly elderly people reaching a rate of 44 million until now. Depending upon certain possibilities, many hypothesis were proposed related to AD; out of which, one is Ca2+ hypothesis. According to this hypothesis, disturbance in Ca2+ signaling pathway due to certain reasons, such as accumulation of beta-amyloid proteins, ER stress, cytochrome c activation etc., causes AD. Due to less clinical research, only few FDA approved pharmaceuticals are available for treatment of AD. Reviewed studies suggest that Ca2+ channel blocker and initiator may play an important role in cure of AD