Cyclin-D1 utility in classification of endometrial stromal sarcomas and segregation from other uterine sarcomas

ABSTRACT

Context Endometrial stromal sarcomas [ESSs] are rare mesenchymal tumors of uterus which accounts for less than 10% of all uterine sarcomas. Gene rearrangement studies unveil their genetic heterogeneity with the discovery of specific YWHAE-FAM22 gene fusion. According to recent WHO classification of endometrial stromal tumors all Endometrial stromal sarcomas with this fusion are labeled as high grade-Endometrial Stromal Sarcomas [HG-ESS]. Immunohistochemically HG-ESSs with YWHAE- FAM22 translocation express nuclear Cyclin D1 positivity which can be used as a surrogate immunohistochemical marker for this translocation