Association between the hepatic lipase promoter region polymorphism [-514 C/T] and the presence and severity of premature coronary artery disease

ABSTRACT

Background: hepatic lipase [HL] plays a crucial role in lipid metabolism, but there is debate about whether HL acts in a more pro- or more anti-atherogenic fashion. We aimed to examine the relationship between the -514 C/T polymorphism within the HL gene [LIPC] and the risk of angiographically determined premature coronary artery disease [CAD]