Effects of low dose radiation on the expression of proteins related to DNA repair requiring caveolin-1 in human mammary epithelial cells

ABSTRACT

Background: Radiotherapy is an effective and important therapeutic method for breast cancer, but at the same time it has a radiation-induced bystander effect on normal tissue around the tumor. Repair of double-strand breaks [DSBs] by normal cells can reduce the extent of damage caused by this effect. Caveolin-1 [Cav-1] is an important regulatory molecule in cell signal transduction. However, the response of normal human mammary epithelial cells following low dose radiation [LDR]- induced DSBs and the role of Cav-1 in the repair of the DSBs are not clear. The present study examined the DNA damage repair mechanism triggered by LDR in human mammary epithelial cells