rs1127354 polymorphism in ITPA is associated with susceptibility to infertility

ABSTRACT

Objective: Infertility is a common human disorder which is defined as the failure to conceive for a period of 12 months without contraception. Many studies have shown that the outcome of fertility could be affected by DNA damage. We attempted to examine the association of two SNPs [rs1127354 and rs7270101] in ITPA, a gene encoding a key factor in the repair system, with susceptibility to infertility