Epigenetic aberration of FMR1 gene in infertile women with diminished ovarian reserve

ABSTRACT

Objective: The diminished ovarian reserve [DOR] is a condition characterized by a reduction in the number and/or quality of oocytes. This primary infertility disorder is usually accompanied with an increase in the follicle-stimulating hormone [FSH] levels and regular menses. Although there are many factors contributing to the DOR situation, it is likely that many of idiopathic cases have genetic/epigenetic bases. The association between the FMR1 premutation [50-200 CGG repeats] and the premature ovarian failure [POF] suggests that epigenetic disorders of FMR1 can act as a risk factor for the DOR as well. The aim of this study was to analyze the mRNA expression and epigenetic alteration [histone acetylation/methylation] of the FMR1 gene in blood and granulosa cells of 20 infertile women