Association of RAGE gene polymorphism with type2 diabetes mellitus in local population

ABSTRACT

Objectives: Type-2 diabetes mellitus [T2DM] is an endocrine disease having a significant genetic component. Polymorphisms of many genes may affect hereditary vulnerability of the disease that is characterized by insulin resistance and islet disorder. As the genetic basis of T2DM can vary between ethnic groups, it is important to investigate the genetic link of T2DM in Pakistani populace. This study was aimed to assess the association of receptor for advanced glycation end product [RAGE] gene polymorphism [-429T>C] with Type-2 diabetes mellitus within local populace