IBJ-Iranian Biomedical Journal. 2018; 22 (2): 99-106
em Inglês
| IMEMR
| ID: emr-192456
ABSTRACT
Background:
Acute myeloblastic leukemia [AML] is a clonal disorder due to bone marrow failure and uncontrolled proliferation of myeloid lineage. Acute promyelocytic leukemia [APL] is a subtype of AML. Heterocyclic compounds, such as indole, are considered as attractive candidates for cancer therapy, due to their abundance in nature and known biological activity. Sal-like protein [SALL4] is a zinc finger transcription factor involving in the multi-potency of stem cells, in the NB4 cell line. This study was aimed to evaluate the effects of basal indole and its new derivative, 2-[1-[[2, 4-Aril]imino]-2,2,2-trifluoroethyl] phenyl-1H Indole-3- carbaldehyde [TFPHC], on the expression of SALL4
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Fatores de Transcrição
/
Expressão Gênica
/
Células Cultivadas
/
Linhagem Celular Tumoral
/
Proteína com Dedos de Zinco da Leucemia Promielocítica
/
Indóis
Idioma:
Inglês
Revista:
Iran. Biomed. J.
Ano de publicação:
2018
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