Hepatogenous diabetes chronic active hepatitis

ABSTRACT

In order to study the possibility and mechanism of occurrence of diabetes in cases of chronic active hepatitis [CAH], 15 patients with this disease were divided into group [A] in which CAH occurred on top of normal liver and group [B] in which the disease occurred on top of bilharzial hepatic fibrosis [BHF]. Ten healthy volunteers of matched age, sex were included as a control group. Liver function tests, LE cells, fasting and postpr and ial blood glucose level, HBsAg, IgG and IgM, glycosylated hemoglobin, radioimmunoassay of fasting and postpr and ial C-peptide and insulin were done. The results showed high incidence of CAH in patients with BHF. Normal fasting insulin level was present in 66.6% of all studied cases. Fasting hyperinsulinemia was present in 26.6% of cases. Postpr and ial immunocreative insulin [IRI] showed significant difference between patients and control cases, there was significant increase in postpr and ial IRI in group A. No positive correlation between fasting C-peptide and fasting IRI was detected, but postpr and ial C-peptide showed positive correlation in relation to postpr and ial IRI. The significance and explanation of these results were included in the text