Fasting urine hydroxyproline / creatinine as estimates of bone resorption in postmenopausal women

ABSTRACT

Serum level of alkaline phosphatase [as estimate of bone formation] and urinary levels of hydroxyproline/creatinine [HPR/CR] and calcium/creatinine [Ca/CR] ratios [as estimates of bone resorption] together with serum calcium and phosphorus levels were determined in 10 healthy premenopausal females and in 13 postmenopausal women. Serum phosphorus level together with urinary HPR/CR and Ca/CR ratios were significantly increased after menopause, meanwhile serum calcium was decreased, while no significant difference was noticed when the premenopausal and postmenopausal women were compared with respect to serum alkaline phosphatase. Both urinary HPR/CR and Ca/CR ratios were found to be negatively correlated to the duration after menopause. Correlation between HPR/CR and Ca/CR in fasting urine samples of postmenopausal women was of high significance: