effects of melilotus officinalis extract on expression of daxx, nfkb and vegf genes in the streptozotocin-induced rat model of sporadic alzheimer's disease

ABSTRACT

Background: Possible mechanisms of Alzheimer Disease [AD] such as inflammation and oxidative stresses in the brain led us to investigate potential AD therapeutics of Melilotus officinalis, an herbal extract, with possible role as an anti-inflammatory and anti-oxidant agent. Among different genes which had important role in Sporadic AD [SAD], three genes including DAXX, NFkB and VEGF have shown significant statistical diversity in the brains of Alzheimer patients