Evaluating the frequency of aac[6']-IIa, ant[2'']-I, intl1, and intl2 genes in aminoglycosides resistant Klebsiella pneumonia isolates obtained from hospitalized patients in Yazd, Iran

ABSTRACT

Background: Klebsiella pneumoniae [K. pneumoniae] is an opportunistic pathogen that could be resistant to many antimicrobial agents. Resistance genes can be carried among gram-negative bacteria by integrons. Enzymatic inactivation is the most important mechanism of resistance to aminoglycosides. In this study, the frequencies of two important resistance gene aac[6']-IIa and ant[2'']-I, and genes coding integrase I and II, in K. pneumonia isolates resistant to aminoglycosides were evaluated