Study of the hepatoprotective activity of methanolic extract of feijoa sellowiana fruits against MDMA using the isolated rat liver perfusion system
IJPR-Iranian Journal of Pharmaceutical Research. 2013; 12 (1): 85-91
em Inglês
| IMEMR
| ID: emr-193144
ABSTRACT
Liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plants. Feijoa sellowiana [Myrtaceae] is an evergreen bush native to southern areas of South America, as well as Iran where the fruits are very popular. Feijoa has shown a potent antimicrobial effect. Morever, the antioxidant activity of total Feijoa extract has also been reported. MDMA or ecstasy is a ring-substituted amphetamine derivative which has been abused as a widespread recreational drug by the young generation. Liver is a target organ for MDMA toxicity. In fact, this sense MDMA is metabolized by cytochromes P[450]2D, 2B and 3Aand reactive metabolites are readily oxidized to the corresponding o-qiuinones and reactive oxygen species [ROS]
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Índice:
IMEMR (Mediterrâneo Oriental)
Idioma:
Inglês
Revista:
Iran. J. Pharm. Res.
Ano de publicação:
2013
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