Electrochemical synthesis of novel 1, 3-indandione derivatives and evaluation of their antiplatelet aggregation activities

ABSTRACT

Electrochemical oxidation of some selected catechol derivatives, using cyclic voltammetry, in the presence of different 2-aryl-1, 3-indandiones as nucleophiles, resulted in electrochemical synthesis of new 1, 3- indandione derivatives in an undivided cell in good yield and purity. A Michael addition mechanism was proposed for the formation of the analogs based on the reaction conditions which were provided in electrochemical cell. The in-vitro antiplatelet and anticoagulant activity of these compounds was evaluated, using arachidonic acid [AA] and adenosine diphosphate [ADP] as the platelet aggregation inducers. The results show that the incorporation of catechol ring in 1, 3-indandione nucleus leads to the emergence of antiplatelet aggregation activity in these compounds. The compounds may exert their antiaggregation activity by interfering with the arachidonic acid pathway