Analysis of MLH3 C2531T polymorphism in Iranian women with unexplained infertility

ABSTRACT

Background: meiotic genes are very important candidates for genes contributing to female and male infertility. Mammalian MutL homologues have dual roles in DNA mismatch repair [MMR] after replication errors and meiotic reciprocal recombination. The MutL homologs, MLH1 and MLH3, are crucial for meiotic reciprocal recombination and human fertility. In this study the functional polymorphisms of MLH3C2531T was investigated in Iranian women with unexplained infertility