Analysis of immumoreactivity of heterologously expressed non-structural protein 4B [NS4B] from hepatitis C virus [HCV] genotype 1a

ABSTRACT

Background: Detection of hepatitis C virus specific antibodies is the initial step in chronic HCV diagnosis. HCV NS4B is among the most immunogenic HCV antigens and has been widely used in commercial Enzyme Immunoassays [EIA]. Additionally, NS4B, a key protein in the virus replication, can be an alternative target for antiviral therapy