Antinociceptive effect of the aqueous extract obtained from Foeniculum vulgare in mice: the role of histamine H[1]] and H[2] receptors

ABSTRACT

Foeniculum vulgare [fennel] has been widely used in traditional medicine for treatment of various diseases including pediatric colic. This study was designed to assess the antinociceptive effects of aqueous extract of F. vulgare on visceral pain and possible involvement of opioidergic, serotonergic, adrenergic and histaminergic systems