Spectrophotometric method for the determination of Gemifloxacin mesylate in pure and tablet dosage form

ABSTRACT

A Spectrophotometric method for the determination of Gemifloxacin mesylate [GFX] is developed and validated according to ICH guidelines. GFX is a fluoroquinolone that is used in the treatment of pneumonia. The analysis of the pure drug was carried out at its 'k[max] 270 nm. The method was linear from 0.5-5microg/mL, r[2] 0.999 and equation is 0.102-0.000. The % RSD for inter-day [0.969%] and intra-day [0.714%] assuring a good precision and accuracy was close to 100%. Limit of detection and Limit of quantification were 0.197 and 0.599|ug/mL, respectively