Preparation and characterization of some thiomalato-metal complexes that have a therapeutic interest

The present article has been carried out to prepare with high yield a thiomalato-gold[I] complex which is used as an antirheumatic drug and is sold under the name myochrisin, in addition to thiomalato complexes of copper, silver and platinum complexes expected to be a therapeutic value. The composition and the optical and structural characteristics of various prepared complexes were determined by using chemical as well as thermal analyses, electronic absorption spectra, infrared spectra, mass spectra and electron spin resonance. The different complexes can be prepared with yields exceeding 75%. These findings indicate that the thiomalato-gold[I] complex can be manufactured on an economic basis